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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Bone marrow mesenchymal stem cells and their derived exosomes resolve doxorubicin-induced chemobrain: critical role of their miRNA cargo

Fig. 7

Bone marrow stem cell (BMSC) and their exosome (BMSCs-Exo) treatment restore hippocampal neurotropic and synaptic growth factor, functional neurotransmitters, and hippocampal β-catenin expression in doxorubicin (DOX)-induced chemobrain in rats. A A bar chart representing the protein expression induction of BDNF in different rat groups. B A bar chart representing the % of mRNA expression induction of FGF-2 in different rat groups. C A bar chart representing the quantification of acetylcholinesterase (AChE) in different rat groups. D A bar chart representing the % of mRNA expression induction of Syp in different rat groups. Representative image reflecting immunohistochemical staining of SY 38 in E control group showing moderate expression of SY 38 in hippocampal sections, F DOX-induced chemobrain group showing minimal expression of SY 38, G group treated with BMSCs showing marked expression of SY 38, and H group treated with BMSCs-Exo showing moderate expression of SY 38. I A bar plot reflecting the quantitative image analysis for SY 38 immunohistochemical staining expressed as area percent. Representative image reflecting immunohistochemical staining of β-catenin in J the control group showing marked expression of β-catenin in hippocampal region, K DOX-induced chemobrain group showing minimal expression of β-catenin in hippocampal region, L BMSC-treated group showing marked expression of β-catenin, and M BMSCs-Exo-treated group showing marked expression of β-catenin. N A bar plot reflecting quantitative image analysis for β-catenin immunohistochemical staining expressed as area percent. Data in AD (n = 6), I, N (n = 4) are presented as mean ± SEM. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. a Significantly different from the control group at p < 0.05. b Significantly different from the DOX group at p < 0.05

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