Fig. 8

Effects of bone marrow stem cell (BMSC) and their exosome (BMSCs-Exo) treatment on Wnt/β-catenin and hedgehog signaling genes and transcription factors in doxorubicin (DOX)-induced chemobrain in rats. A A bar chart representing the % of mRNA expression induction of Wnt-3a in different rat groups. B A bar chart representing the % of mRNA expression induction of Wnt-7b in different rat groups. C A bar chart representing the % of mRNA expression induction of Wnt-2 in different rat groups. D A bar chart representing the % of mRNA expression induction of FZD1 in different rat groups. E A bar chart representing the % of mRNA expression induction of sonic hedgehog (shh) in different rat groups. F A bar chart representing the % of mRNA expression induction of patched-1 (Ptch-1) in different rat groups. G A bar chart representing the % of mRNA expression induction of the transcription factor Gli-1 in different rat groups. H A bar chart representing the % of mRNA expression induction of Sox2 in different rat groups. I A bar chart representing the % of mRNA expression induction of Prox1 in different rat groups. J A bar chart representing the % of mRNA expression induction of NeuroD1 in different rat groups. K A bar chart representing the % of mRNA expression induction of DCX in different rat groups. L A bar chart representing the % of mRNA expression induction of NeuN in different rat groups. Data are presented as mean ± SEM. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test (n = 6). ^a Significantly different from the control group at p < 0.05. ^b Significantly different from the DOX group at p < 0.05