Fig. 5
From: Rspo3 regulates the abnormal differentiation of small intestinal epithelial cells in diabetic state
miRNA expression profiles were evaluated in the IECs from mice with DM. a The red point in the plot represents the differentially expressed miRNAs with statistical significance in the volcano plot. b Microarray analysis was used to evaluate the miRNA expression profiles in the db/db mice. C, control mice; D, diabetic mice. c Rspo3 targets Rspo3, as shown by an analysis of publicly available algorithms. d RT-qPCR revealed that miR-380-5p expression was downregulated in the IECs of the db/db mice. e In situ hybridization with a DIG-labeled LNA-miR-380-5p probe showed that miR-380-5p was predominantly localized near the crypt base. Scale bar, 50 μm; mean ± SD, n = 6; *P < 0.05