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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Amnion epithelial cells are an effective source of factor H and prevent kidney complement deposition in factor H-deficient mice

Fig. 2

hAEC reduced serum C3 levels and glomerular C3 and C9 staining in Cfh−/− mice. Serum C3 level (A) and semiquantitative scores of glomerular C3 (B) and C9 (D) staining in Cfh−/− mice given PBS or hAEC injections and sacrificed either 10 or 40 days later. Green horizontal lines indicated statistically significant differences (P < 0.05) between groups. Mice given PBS as controls for hAEC and sacrificed 10 or 40 days after injection exhibited non-significant differences in all the considered parameters (Supplemental Figure S2) and were therefore pooled in a single control group (n = 8). Panels C and E show representative images of C3 (green) and C9 (red) deposits in kidneys counterstained with DAPI (blue) of Cfh−/− from the indicated experimental group. Original magnification × 630

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