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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Amnion epithelial cells are an effective source of factor H and prevent kidney complement deposition in factor H-deficient mice

Fig. 4

hAEC induced cellular and antibody response. Number expressed as cells/high power field (HPF) of liver infiltrating CD4+ T cells (A) and CD8+ T cells (C) in Cfh−/− mice given PBS or analyzed either 10 or 40 days post-hAEC-injection. Horizontal lines indicate statistically significant differences (P < 0.05) between groups. Panels B and D are representative images of CD4+ or CD8+ T cells in livers from Cfh−/− mice euthanized 10 days post-hAEC injection. Panel E provides a representative image of co-localization of CD8+ T cells (red) with HNA+ hAEC (green) 10 days post-hAEC injection in Cfh−/− mice. Original magnification × 400. F FACS histograms for murine antibody binding to hAEC after exposing human cells to serum from PBS- or from hAEC-treated Cfh−/− mice analyzed either 10 or 40 days after human cell injection

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