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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers

Fig. 3

Effects of Gadlium treatment on the SHPC behavior, and characterization of SHPCs in livers transplanted with BM-MCs. a IL17rb gene expression in SHPCs of livers receiving Thy1+ cells and BM-MCs transplantation was confirmed by qRT-PCR. Kupffer cells in Ret/PH-treated rat livers were inactivated by administering GdCl3 24 h before cell transplantation. The number of SHPC clusters per liver area (b) and the size of SHPC clusters (c) were measured using liver samples of 14 days after cell transplantation. Bars show SEs. Asterisks indicate statistically significant differences; p < 0.05. d Clustering analysis of the gene profiles of SHPCs with Thy1+ cells and BM-MCs. Significantly upregulated genes were analyzed using clustering methods in Thy1+ cells and BM-MCs

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