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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers

Fig. 9

Administration of EVs derived from BM-MCs transfected with miR-146a-5p to Ret/PH rat livers. EVs derived from the conditioned medium of cultured BM-MCs transfected with miR-146a-5p for 48 h were administered, and the livers were examined at 14 days post-administration. a The amounts of miR146a-5p in the EVs secreted by BM-MCs with and without transfection were confirmed using qRT-PCR. Bars show SEs. Asterisks indicate statistically significant differences; p < 0.05. b The number of SHPC clusters per liver area and c the number of cells per cluster is shown. Bars show SEs and asterisks indicate statistically significant differences, p < 0.05. d Photos of SHPC clusters in the livers of control, EVs (normal EV), EVs secreted by BM-MCs transfected with negative control (NT) or miR-146a-5p (miR-146a). The samples were stained with H-E. SHPCs clusters were surrounded by dotted lines: scale bar, 200 μm

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Stem Cell Research & Therapy

ISSN: 1757-6512