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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: The whole profiling and competing endogenous RNA network analyses of noncoding RNAs in adipose-derived stem cells from diabetic, old, and young patients

Fig. 8

Overexpression of miR-145-5p rejuvenated O-ASCs and enhanced their functions. a The proliferation rate of ASCs treated with miR-145-5p, mimic-NC, inh- miR-145-5p, or inh-NC were measured by EdU assay. Scale bar 50 μm. c Images of migratory ASCs given above treatments. Scale bar 50 μm. e β-gal staining assay analysis of the senescent rate of ASCs given above treatments. Scale bar 50 μm. g Images of tube formations in HUVECs treated with conditioned media of ASCs given above treatments. Scale bar 50 μm. i Images of migratory fibroblasts given above treatments. Scale bar 100 μm. b, d, f, h, and j Qualified data shown in a, c, e, g, and i separately. k Western blot analysis of the proteins levels in ASCs after miR-145-5p overexpression. l PCR analysis of the genes expressions in ASCs after miR-145-5p overexpression. *p< 0.05, **p< 0.01, ***p< 0.001, ****p< 0.0001

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