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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: RETRACTED ARTICLE: Exosomal SNHG16 secreted by CSCs promotes glioma development via TLR7

Fig. 6

TLR7 activation was responsible for SNHG16-mediated cancer stem cell transition in vivo. SHG44 and U251 cells that stable expressed si-TLR7 were incubated with exosomes from CSCs transfected with SNHG16 or NC, and then SHG44 and U251 cells were injected into nude mice (n = 10). A, B Growth of tumor xenografts in nude mice. n = 10, *p < 0.05. C, D Representative tumors excised from xenografts in nude mice and tumor weight. n = 4, *p < 0.05. E Immunofluorescence staining for Ki67 to test proliferation viability. Scale bar = 50 μm. n = 4, *p < 0.05. F NFκB activities was examined by EMSA. n = 4, *p < 0.05. G Western blotting for c-Myc expression. n = 4, *p < 0.05

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