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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis

Fig. 1

MiR-375 attenuates the stemness of GC cells. A, B The sphere size and number were examined in GC cells with or without miR-375 overexpression. C The protein expression of stemness markers was evaluated in GC cells with or without miR-375 overexpression. D CD44+ sub-population was determined in GC cells with or without miR-375 overexpression. E The images of tumors derived from different numbers of SGC7901 cells with or without miR-375 overexpression. F The tumor formation rate and confidence intervals for 1/(stem cell frequency) were calculated based on the results shown in E. G The images of tumors derived from different numbers of BGC-823 cells with or without miR-375 overexpression. H The tumor formation rate and confidence intervals for 1/(stem cell frequency) were calculated based on the result shown in G. I HE staining images of lung obtained from mice with injection of GC cells with or without miR-375 overexpression. J The correlation between miR-375 expression and the overall survival probability of GC patients was evaluated using the online analysis tool (http://kmplot.com). Data are presented as the mean ± SD, n ≥ 3, **p < 0.01 vs control, ##p < 0.01 vs LV3-NC

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