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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis

Fig. 3

MiR-375 triggers ferroptosis through targeting SLC7A11. A KEGG pathway enrichment analysis in SGC-7901 cells with or without miR-375 overexpression. B GSEA analysis in SGC-7901 cells with or without miR-375 overexpression. C Transmission electron microscopy (TEM) assay on the mitochondria of GC cells with erastin treatment, miR-375 overexpression, SLC7A11 knockdown, or miR-375 overexpression as well as SLC7A11 overexpression. D Lipid peroxidation level was measured in GC cells with miR-375 overexpression as well as SLC7A11 overexpression or not. *p < 0.05 vs NC, ##p < 0.01 vs miR-375. E Cysteine concentration was examined in the cells as depicted in D. ***p < 0.001 vs si-NC, ##p < 0.01 vs NC+miR-375. F GSH concentration was detected in the cells described in D. **p < 0.01, ***p < 0.001 vs NC, ##p < 0.01 vs NC+miR-375. Data are presented as the mean ± SD, n ≥ 3

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