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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis

Fig. 7

MiR-375 attenuates the stemness of GC cells mainly through inducing ferroptosis. A CD44+ sub-population was examined in GC cells with miR-375 overexpression plus Fer-1, Z-VAD-FMK, or Nec-1 treatment. Data are presented as the mean ± SD, n ≥ 3, *p < 0.05, **p < 0.01 vs LV3-NC+DMSO; ##p < 0.01, ###p < 0.001 vs LV3-miR-375+DMSO. B The expression of stemness markers was detected in the cells depicted in A. C The expression of stemness markers was determined in GC cells with SLC7A11 knockdown plus Fer-1 treatment or not. D The inhibition ratio of erastin was measured in WT and ER cells. Data are presented as the mean ±ean ar ≥ 3, **p < 0.01, ***p < 0.001 vs WT or ER. E CD44+ sub-population was assessed in WT and ER cells with miR-375 overexpression or miR-NC. Data are presented as the mean ±re pre ≥ 3, **p < 0.01 vs control+miR-NC; ns, no significance. F The expression of stemness markers was examined in the cells described in E. G Sphere-formation ability was evaluated in the cells depicted in E

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