Fig. 2
From: Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model
Postoperative in vivo analysis with multimodal imaging. Lines I, II, and III: representative case of submacular hESC-RPE graft at 5, 14, and 28 days after surgery. A Infrared reflectance (IR) images of the posterior fundus. B Blue laser autofluorescence (BAF) images show minimal hyper autofluorescence changes overlapping the hESC-RPE graft which correlate with denude native RPE procedure. C, D Early- and late-phase fluorescein angiography (FA) show no fluorescein leakage over or immediately surrounding the hESC-RPE graft (white outlines); some staining is present at the site of the denude RPE wound and surrounding the retinotomy (solid red arrows). E, F Horizontal and vertical SD-OCT scans through the middle of the implants (as shown in inserts). Outer retinal reflectance layers on SD-OCT are grossly preserved both over the hESC-RPE graft (white triangles indicate the edges of the graft) and the remaining bleb area, except the retinotomy site (red arrows). Scale bars, A–D 2mm and E, F 200 μm