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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model

Fig. 5

Evaluation of photoreceptor preservation. Epifluorescent and brightfield micrograph overlays of L/M-cone opsin and rhodopsin immunolabelings show varying degrees of photoreceptor outer segment (POS) preservation above the graft. A1–A4 Staining at the fovea from naive control animal. B1–B4 and C1–C4 Staining at the fovea from 2 different hESC-RPE-transplanted animals (cases 9 and 8, respectively). White boxes mark the sites for enlargements to the right column. Although positive signals of both opsin/rhodopsin and areas of POS preservation (B1–B4) are present in all examined eyes (n=8) above/around the hESC-RPE graft, the eyes also contain areas where increased localization of opsins to the photoreceptor cell bodies is present or the POS are completely disrupted (C1–C4). Scale bars, A1, A3, B1, B3, C1, C3 200 μm and A2, A4, B2, B4, C2, C4 100 μm. The nuclei counterstained with DAPI

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