Skip to main content
Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Methylsulfonylmethane enhances MSC chondrogenic commitment and promotes pre-osteoblasts formation

Fig. 1

MSM improves chondrogenesis. MSM addition did not affect the cells number (A); it upregulated the chondrogenic transcription factor SOX9 (B) and COL2A1 expression (C) during chondrogenic differentiation. MSM enhanced SOX9 expression in chondrocytes and restored the negative effects of IL-1β (D). MSM supplement increased the production of aggrecan by chondrocytes, even in the presence of IL-1β (E) (a: control; c: MSM treated; c: IL-1β + MSM treated). MSM upregulated the expression of chondrogenic genes in zebrafish larvae after 7 (9 dpf) (F) and 14 (16 dpf) (G) days of treatment. *p<0.05; **p<0.01

Back to article page