Table 1 Study assessment based on inclusion and exclusion criteria according to the PICOS (patients, intervention, comparator, outcomes, and study design) approach (https://ro.ecu.edu.au/cgi/viewcontent.cgi?referer=https://www.google.it/&httpsredir=1&article=1010&context=ecupres)
Inclusion criteria | |
P—patients | Age 18–80 years, patients with soft tissue defects, chronic wound, scars, outcomes of scars, acne scars, post-traumatic scars, burns, outcomes of burns |
I—intervention | Local injection of autologous AD-MSCs, SVF, and F-GRF |
C—comparator | Any type of control, internal, external, and different product |
O—outcomes | Healing time, soft tissue volume maintenance, skin quality, scar reduction |
S—study design | Clinical trial, randomized clinical trial, case-series, case report, case-controlled studies |
Exclusion criteria | |
P—patients | Other types of defects and pathologies, patients with platelet disorders, thrombocytopenia, anti-aggregating therapy, use of pharmacological therapeutics targeting WH as advanced dressing, hyaluronic acid, mononuclear cell therapy—platelet-rich plasma was tested as control in PRP studies, bone marrow aplasia, uncompensated diabetes, sepsis, cancer |
I—intervention | Allogeneic use of AD-MSCs, SVF, and F-GRF, dermal substitute, advanced dressing, hyaluronic acid, steroid injections, surgical procedures |
C—comparator | Not applied |
O—outcomes | Not applied |
S—study design | Expert opinion, comments, letter to the editor, preclinical model (animal studies), in vitro studies, articles identified as bias—not correct match with the keywords used and with the treatment, shorter follow-up than 3 months, review, and systematic review. No limitations were applied on ethnicity or method of fat processing |