Fig. 1

Effects of BNN-20 administration on the total dopaminergic cell number of the “weaver” SNpc. A Dot plot of stereologically calculated total TH+ cell numbers in the SNpc of wild-type (WT) and “weaver” (wv) mice, treated with either BNN-20 or saline (sal) from P14 to P40 or to P60 (n = 4 per group) [a: p < 0.001 compared to WT P14, b: p < 0.01 compared to wv P14, c: p < 0.001 compared to wv P40, d: p < 0.001 compared to wv P60, using two-way ANOVA followed by Bonferroni post hoc test (p = 0.000, F = 52.160 for drug, p = 0.000, F = 100.234 for genotype and p = 0.000, F = 12.114 for the interference of the two variables). Error bars are SDs.]. B Representative images of the SNpc using DAB immunohistochemistry against TH [scale bar= 200 μm]