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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs

Fig. 3

BMSC and BMSC-EV treatments reduce abnormal deposition of collagen in a mouse SSc model. a Masson’s trichrome staining of representative skin sections from mouse skin tissue and blue staining for collagens. Scale bar 200 μm. b The collagen content of skin tissues was measured by hydroxyproline assay. c, d mRNA levels of Col1 and Fn1 in the lesional skin were assessed by real-time PCR. e–g The protein expression of COL1 and FN1 in the skin was detected by western blot

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