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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs

Fig. 5

BMSC-EV treatment decreases myofibroblast differentiation into fibroblasts. a, b Representative images of TGF-β1- and α-SMA-positive cells detected by immunohistochemical staining. Scale bar 100 μm. c, e Quantitative analysis of TGF-β1- and α-SMA-positive cell numbers. d, f The expression levels of α-SMA and TGF-β1 were detected with real-time PCR. g, h, i The protein expression of TGF-β1 and α-SMA in the skin was detected by western blot. BLM: bleomycin; EVs: BMSC-derived EVs; α-SMA: α-smooth muscle actin; TGF-β1: transforming growth factor-β1

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Stem Cell Research & Therapy

ISSN: 1757-6512