Fig. 4

CXCR7 upregulates PPAR, WNT, Hedgehog, and Notch signaling on MSCs. Up- and downregulated mRNA profiling in terms of TGF-β (a), oxidative stress (b), hypoxia (c), PPAR (d), WNT (e), Hedgehog (f), NF-κB (g), JAK/STAT (h), P53 (i), and Notch (j) signaling pathways for MSCs with or without CXCR7 overexpression using the Human Signal Transduction Pathway Finder RT2 Profiler™ PCR Array. k PPAR, WNT, Hedgehog and Notch signaling activities in MSCs with or without CXCR7 overexpression using the reporter assays. Data are means ± SD (n=6). *P < 0.001 compared with native MSCs (WT). l PPAR, WNT, Hedgehog, and Notch signaling activities in MSCs with or without the CXCR7 antagonist, CCX771, or agonist, TC14012, treatment for 3 days. Data are means ± SD (n=6). *P < 0.001 compared with the untreated group (WT)