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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Gain of CXCR7 function with mesenchymal stem cell therapy ameliorates experimental arthritis via enhancing tissue regeneration and immunomodulation

Fig. 6

MSCs with CXCR7 gain-of-function decrease the histopathological features and severity of arthritis. ad Representative histopathologies of the ankle joints stained with haematoxylin and eosin (H&E) and histologic joint scores in normal rats or rats with collagen-induced arthritis (CIA) receiving vehicle (PBS), control vector-expressing MSC (control MSCs), CXCR7-expressing MSC (CXCR7-MSCs), native MSCs (MSC), vehicle-primed MSC, CCX771-primed MSC, or TC14012-primed MSC treatment on day 28. Data are means ± SD (n=6–8). *P < 0.01 compared with the normal group without CIA. # P < 0.01 compared with the CIA group without any treatment. e-h Representative histopathologies of the ankle joints stained with Safranin-O and histologic joint scores in normal rats or rats with CIA receiving vehicle (PBS), control vector-expressing MSC (control MSCs), CXCR7-expressing MSC (CXCR7-MSCs), native MSC (MSCs), vehicle-primed MSC, CCX771-primed MSC, or TC14012-primed MSC treatment on day 28. Data are means ± SD (n=6–8). *P < 0.01 compared with the normal group without CIA. # P < 0.01 compared with the CIA group without any treatment

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