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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6

Fig. 3

MSCs-Exo alleviated TNBS-induced acute colitis. a Schematic diagram of the experimental design. Mice were intraperitoneally injected with MSCs-Exo 1 day after enema of TNBS, and mice were sacrificed 5 days after TNBS treatment. Pre: before treatment; i.r., intrarectal delivery; i.p., intraperitoneal. b Severe diarrhea and bloody stool in the TNBS+PBS mice at day 3. The body weight (c) and DAI (d) of each group of mice were recorded daily (n = 5 per group). e Gross morphology and length of colonic tissues in the control, TNBS+PBS, and TNBS+Exo groups at day 5. f The infiltration of neutrophils into colon was quantified by the MPO activity. g Histopathological changes were evaluated by hematoxylin and eosin (H&E) staining of colon tissue and histological score. Original magnification, × 40 (upper), × 100 (lower). Data are presented as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001, and ns indicates P > 0.05

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