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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6

Fig. 4

MSCs-Exo alleviated intestinal mucosal barrier dysfunction in colitis. a PAS staining showing the number of goblet cells (purple-red) in the colon. Original magnification, × 100 (upper), × 200 (lower). b Quantitative analysis showing the number of goblet cells. c Concentration of FITC-D in serum showing the permeability of the intestinal mucosa in FITC-D-treated mice. The ultrastructural morphology of tight junctions (white arrows) and microvilli (white arrowheads) were observed under TEM. Decreased tight junction electron density and loose microvilli reflecting the characteristics of intestinal mucosal barrier destruction. Scale bar, 1 μm. e Immunohistochemistry showing the expression levels of tight junction proteins ZO-1, Occludin, and Claudin-1 in the intestinal epithelium. Images were taken at × 400 magnification. f Quantitative analysis of the expression levels of the tight junction markers ZO-1, Occludin, and Claudin-1 in colonic mucosa by western blot. Data are presented as mean ± SD. *P < 0.05 and **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512