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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6

Fig. 5

Treatment of MSCs-Exo altered cytokine profile in colon tissue. a Volcano plot showing differential expression of multiple mRNAs from colon tissue in the DSS + Exo group compared with the DSS + PBS group. b The hierarchical clustering representing cytokine mRNA at significantly different levels between the DSS + Exo group and the DSS + PBS group (fold-change>2, P < 0.05). In the heatmap, high expression is shown in red, and low expression is shown in blue. c qPCR results showing the mRNA levels of IL-4, TGF-β, CXCL14, IL-1β, IL-11, and IL-12 in the two groups. n = 5 per group. Data are presented as mean ± SD. *P < 0.05 and **P < 0.01

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