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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6

Fig. 9

MSCs-Exo repaired colonic mucosal barrier via TSG-6 in colitis mice. a The number of goblet cells was significantly reduced in mice injected with siTSG-6 Exo compared to the DSS + siNC Exo group. b The histogram representing the number of goblet cells. c The histogram showing the concentration of FITC-D in the serum in each group of mice. d TEM images showing the ultrastructural morphology of tight junctions (white arrows) and microvilli (white arrowheads). The damage of tight junction and microvilli structure in the DSS + siTSG-6 Exo group were more serious than that in the DSS + siNC Exo group. Scale bar, 1 μm. e Immunohistochemistry analysis showing the expression levels of the tight junction proteins ZO-1, Occludin, and Claudin-1 in the intestinal epithelium. Images were taken at × 400 magnification. f Quantitative analysis of the expression of tight junction markers ZO-1, Occludin, and Claudin-1 in colonic mucosa by Western blot. Data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, and ns indicates P > 0.05

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