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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Placental chorionic plate-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating macrophage polarization via secreting TSG-6

Fig. 1

Survival and distribution of exogenous CP-MSCs in rodent animal models of SAP. A The bioluminescence imaging was used to monitor the survival status of exogenous CP-MSCs in SAP at 7-day intervals continuously. B CP-MSCs were labeled with CM-Dil to track the distribution of CP-MSCs in SAP rats; all rats were sacrificed 72 h after the first CP-MSC transplantation; and the lung, heart, liver, pancreas, spleen, kidney, duodenum, and colon were collected, then observed the distribution of CP-MSCs in different tissues under a fluorescence microscope. Scale bars, 200 μm. C CP-MSCs without CM-Dil labeling. Scale bars, 50 μm. D CP-MSCs labeled with CM-Dil were inoculated in a culture flask and placed in a cell culture incubator, and CM-Dil does not affect the proliferation of CP-MSCs. Scale bars, 50 μm. E The CCK-8 assay was used to evaluate the effect of CM-Dil on the proliferation of CP-MSCs. Data are represented as mean ± SEM (n = 6). F Distribution was assessed from the lung, liver, spleen, duodenum, colon, pancreas, heart, and kidney sections after CM-Dil-labeled with CP-MSC injection in rats with or without SAP. The numbers of CM-Dil-labeled CP-MSCs represent the mean ± SEM of at least 5 fields (n = 5). Significance is indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001; NS, no significant

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