Fig. 2

CP-MSCs reduced pancreatic injury and systemic inflammatory in SAP rats. A Schematic diagram of exogenous CP-MSC transplantation in SAP rats. TCA, sodium taurocholate. B H&E staining of pancreas tissue. Scale bars, 50 μm. Histopathological scores for the pancreas, including edema, inflammation infiltrate, acinar necrosis, and hemorrhage. C Pancreatic myeloperoxidase (MPO) activity. MPO is unique to mature neutrophils, so pancreatic MPO activity can be used to reflect the infiltration of neutrophils in the pancreas. D Pancreas/body-weight ratio is used to quantify pancreatic edema. E, F Serum amylase and lipase activity. G The mRNA expression levels of pro-inflammatory cytokines (IL-1β and TNF-α) and anti-inflammatory cytokines (IL-4 and IL-10) in the pancreatic tissue. H The concentrations of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6) and anti-inflammatory cytokines (IL-10, IL-4, and TGF-β) in serum. All graphs show mean ± SEM (n = 8). Significance is indicated as follows: *p < 0.05; **p < 0.01; ***p < 0.001; NS, no significant