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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Placental chorionic plate-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating macrophage polarization via secreting TSG-6

Fig. 5

The protective effect of CP-MSCs on SAP rats is significantly weakened after the depletion of M2 macrophages. A Schematic diagram of exogenous CP-MSC transplantation in SAP rats. GdCl3 or MCLs were injected into the SD rats via the tail vein immediately after the operation, and CP-MSCs were injected via the tail vein at 6h and 30h after operation. The therapeutic effect of CP-MSCs on SAP rats was evaluated 72h after the first CP-MSC transplantation. B H&E staining of pancreas tissue. Scale bars, 50 μm. C Histopathological scores for the pancreas, including edema, inflammation infiltrate, acinar necrosis, and hemorrhage. D Pancreas/body-weight ratio. E Pancreatic MPO activity. Serum amylase (F) and lipase (G) activity. H The mRNA expression levels of pro-inflammatory factors (IL-1β and TNF-α) and anti-inflammatory factors (IL-10 and IL-4) in the pancreatic tissue. I The concentrations of pro-inflammatory factors (IL-1β and TNF-α) and anti-inflammatory factors (IL-4 and IL-10) in serum. All graphs show mean ± SEM (n = 6). Significance is indicated as follows: *p < 0.05; **p < 0.01; ***p < 0.001; NS, no significant

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