Table 1 List of mouse ECM and adhesion molecule genes in the Bu/Cy group whose expression levels were changed more than two-fold compared to the normal group

Basement membrane constituents

Col4a1

NM_009931

Collagen type IV alpha 1

12.51

Col4a2

NM_009932

Collagen type IV alpha 2

5.95

Sparc

NM_009242

Secreted acidic cysteine rich glycoprotein

5.24

Lamc1

NM_010683

Laminin, gamma 1

3.95

Timp2

NM_011594

Tissue inhibitor of metalloproteinase 2

2.55

Collagens and ECM structural constituents

Col6a1

NM_009933

Collagen type VI alpha 1

3.92

Col1a1

NM_007742

Collagen type I alpha 1

2.39

Other ECM molecules

Tnc

NM_011607

Tenascin C

7.91

Ecm1

NM_007899

Extracellular matrix protein 1

4.67

Ctgf

NM_010217

Connective tissue growth factor

2.10

ECM proteases

Mmp12

NM_008605

Matrix metallopeptidase 12

21.45

Mmp15

NM_008609

Matrix metallopeptidase 15

11.89

Adamts5

NM_011782

A disintegrin-like and metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)

5.33

Adamts2

NM_175643

A disintegrin-like and metallopeptidase with thrombospondin type 1 motif, 2

5.20

(ECM proteases)

Mmp2

NM_008610

Matrix metallopeptidase 2

4.20

Mmp14

NM_008608

Matrix metallopeptidase 14

2.70

Adamts1

NM_009621

A disintegrin-like and metallopeptidase with thrombospondin type 1 motif, 1

2.50

Mmp8

NM_008611

Matrix metallopeptidase 8

− 38.97

Cell-ECM adhesion

Itga3

NM_013565

Integrin alpha 3

8.77

Itgax

NM_021334

Integrin alpha X

2.89

Itga5

NM_010577

Integrin alpha 5

2.57

Itgav

NM_008402

Integrin alpha V

2.19

Itga4

NM_010576

Integrin alpha 4

− 5.94

Itgam

NM_008401

Integrin alpha M

− 6.29

Transmembrane receptors

Vcam1

NM_011693

Vascular cell adhesion molecule 1

12.94

Icam1

NM_010493

Intercellular adhesion molecule 1

4.96

Cdh2

NM_007664

Cadherin 2

4.36

Selp

NM_011347

Selectin, platelet

3.74

Pecam1

NM_008816

Platelet/endothelial cell adhesion molecule 1

2.26

Sell

NM_011346

Selectin, lymphocyte

− 3.65