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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism

Fig. 4

Changes in cardiac function after MI and hEMSC implantation. a Schematic illustration of in vivo experimental procedures. b Representative M-mode echocardiographic images taken before (baseline), 0 and 28 days after cell transplantation in nude rats that received injection of PBS (PBS control), human bone marrow mesenchymal stem cells (hBMSCs), or human endometrium-derived stem cells (hEMSCs). Ejection fraction (c), Left ventricular internal diameter end systole (LVIDs, d), and end diastole (LVIDd, e) evaluated by echocardiograph. n = 6/group. Representative images of heart sections (f) and Masson’s trichrome staining (g) taken at 28 days after cell transplantation. h Planimetry-based quantification revealed that the scar area was significantly smaller in the hEMSC group, compared to the other 2 groups at 28 days after cell transplantation. Ventricular wall thicknesses for infarct (i), border (j), and septum (k). Significant differences were only found for the border zone, where thicknesses were significantly higher among hEMSC compared to hBMSC groups, and both also significantly higher than the PBS control group. Data are expressed as mean ± SEM. n = 5/group. **p < 0.01 PBS vs hEMSCs, ##p < 0.01 PBS vs hBMSCs, Δp < 0.05 hBMSCs vs hEMSCs, ΔΔp < 0.01 hBMSCs vs hEMSCs

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