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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells

Fig. 5

Global gene expression of pancreatic progenitors under different treatments. a Heatmap of genes upregulated by D4476, Y27632 and nicotinamide treatments and analysis of cell types by Enrichr. Cluster 1, 2, 3, 4, 5, 6, 7 and 8 contain 1071, 206, 344, 364, 376, 96, 243 and 999 genes, respectively; b Heatmap of representative pancreatic progenitor marker genes under Mock, D4476, Y27632, and nicotinamide conditions; c Heatmap and hierarchical clustering of representative genes of endocrine alpha, beta cells under Mock, D4476, Y27632 and nicotinamide conditions compared to hESCs cultured in E8

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Stem Cell Research & Therapy

ISSN: 1757-6512