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Fig. 14 | Stem Cell Research & Therapy

Fig. 14

From: Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat

Fig. 14

The possible mechanism of MSCs against TGF-β1 induced fibrosis in Gal-3 OE HK-2 cells. In empty transfection groups, the variation trends (AH) of each group were similar to Fig. 13. In Gal-3 OE groups, the variation trends of each group were similar to those of the control groups and Gal-3 KD groups, but higher than the same subgroup in Gal-3 KD cells. In TGF-β1+DMEM/12 group, the expression of KIM-1 was also lower than TGF-β1 group, but the ratios of p-GSK3β/GSK3β and TIM1P1/MMP9 were higher than TGF-β1 group. Results were normalized relative to the expression of β-actin. N = 3 (per group). Data are presented as mean ± SD, and analyzed by two-way ANOVA followed by Tukey post hoc testing. *P < 0.05, vs. control group, #P < 0.05, vs. TGF-β1+MSCs-CM group, &P < 0.05, vs. TGF-β1 +DMEM/F12 group, ^P < 0.05, vs. MSCs-CM group; compared empty transfection HK-2 cells with Gal-3 KD HK-2 cells, aP < 0.05, vs. normal group, bP < 0.05, vs. TGF-β1 group , cP < 0.05, vs. TGF-β1+MSCs -CM group, dP < 0.05, vs. TGF-β1+MSCs-CM group, eP < 0.05, vs. MSCs-CM group

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