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Fig. 15 | Stem Cell Research & Therapy

Fig. 15

From: Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat

Fig. 15

Immunocytochemical staining of E-Cadherin and α-SMA in Gal-3 KD and Gal-3 OE HK-2 cells. Gal-3 KD reduced α-SMA and increased E-Cadherin expression in HK-2 cells and that Gal-3 OE showed an opposite trend. TGF-β1 obviously increased α-SMA and decreased E-Cadherin in Gal-3 OE cells which was more than in Gal-3 KD cells. MSCs-CM treatment reduced α-SMA and raised the expression of E-Cadherin in both Gal-3 KD cells and Gal-3 OE cells, but more significant in Gal-3 KD cells than in Gal-3 OE cells. DMEM/F12 also downregulated the expression of α-SMA, worse than the MSCs-CM group. Bar = 100 μm

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