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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Exosome-transported circRNA_0001236 enhances chondrogenesis and suppress cartilage degradation via the miR-3677-3p/Sox9 axis

Fig. 1

circRNA expression profile in the exosomes during the chondrogenesis of hMSCs. a Transmission electron microscopy showed the cup-shaped or round morphology of exosomes isolated from MSCs induced to undergo chondrogenesis. b The particle size and number of the exosomes were determined by nanoparticle tracking analysis (NTA). c Exosomal marker (CD9, CD63, CD81) protein expression of exosomes isolated from MSCs induced to undergo chondrogenesis. d Heat map showing significantly expressed circRNAs with ≥ 2-fold upregulation in MSCs that were induced to undergo chondrogenesis by TGF-β3 treatment for 0 and 21 days. Red and green colors indicate upregulated and downregulated circRNAs, respectively, with high fold change. e, f The top five most significantly differentially expressed exosomal circRNAs were verified. GAPDH was used as an internal control for circRNA expression. The data represent the mean ± SD of three independent experiments on samples from three different donors. *P < 0.05, **P < 0.01, ***P < 0.001. Scale bar, 100 nm

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