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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Exosome-transported circRNA_0001236 enhances chondrogenesis and suppress cartilage degradation via the miR-3677-3p/Sox9 axis

Fig. 6

The exosomal circ_0001236/miR-3677-3p/Sox9 axis regulates cartilage metabolic balance. a Schematic illustration demonstrates the complementarity of the miR-3677-3p seed sequence with circ_0001236. b miR-3677-3p mimic or negative control (NC) was co-transfected with a luciferase reporter construct containing circ_0001236 wild-type (WT) or circ_0001236 mutant (MUT) into HEK293T cells. The luciferase reporter activities are shown. c Schematic illustration demonstrates the complementarity of the miR-3677-3p seed sequence with Sox9. d miR-3677-3p mimic or NC was co-transfected with a luciferase reporter construct containing Sox9 WT or Sox9 MUT into HEK293T cells, and the luciferase reporter activities of Sox9-MUT were markedly higher than that of Sox9 WT. Sox9 expression was regulated by hsa_circ_0001236 and miR-3677-3p (e, f). The experiment was repeated independently three times, and representative results are shown. GAPDH was used as endogenous control. ***P < 0.001

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