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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Bone marrow-derived mesenchymal stem/stromal cells in patients with acute myeloid leukemia reveal transcriptome alterations and deficiency in cellular vitality

Fig. 5

JAK-STAT signaling inhibition was sufficient to counteract defects of cellular vitality of AML-MSCs. a, b The hyperactivated (a) and extensive inhibited (b) genes were involved in multiple signaling pathways in AML-MSCs compared with those in HD-MSCs by KEGG analysis. c GSEA indicated the differentially expressed genes were involved in JAK-STAT signaling pathway subsets in AML-MSCs. d The HeatMap diagram of JAK-STAT signaling pathway-associated genes in AML-MSCs and HD-MSCs. e, g The proliferation ability (e) and apoptotic rate (f, g) of HD-MSCs and AML-MSCs with/without JAK-STAT signal inhibition (JAKi) or activation (JAKa). All data were shown as mean ± SEM (n = 3). *P < 0.05; **P < 0.01; NS, not significant

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Stem Cell Research & Therapy

ISSN: 1757-6512