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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Serum exosomes from young rats improve the reduced osteogenic differentiation of BMSCs in aged rats with osteoporosis after fatigue loading in vivo

Fig. 7

The promotion of osteogenic differentiation by serum exosomes from young rats is partly mediated by miR-19b-3p. A Transfection efficiency of the miR-19b-3p inhibitor. B Under osteogenic induction, BMSCs treated with exosomes with miRNA-19b-3p knockdown BMSCs were stained for ALP after induction. C After miRNA-19b-3p knockdown in exosomes, the mRNA expression levels of ALP, Collagen I, and RUNX2 in BMSCs were reduced, whereas that of the predicted gene PTEN was increased. D WB analysis of the levels of PTEN in BMSCs treated with the NC-exo and KD-exo. The BMSCs of the KD-exo group expressed lower levels of Collagen I and higher levels of PTEN. The data are expressed as the mean ± SEM (n = 3). *P < 0.05, **P < 0.01, ****P < 0.0001

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Stem Cell Research & Therapy

ISSN: 1757-6512