From: Application of mesenchymal stem cell sheet to treatment of ischemic heart disease
Cell type | Cell source | Disease model | Animal species | Number of cells | Groups and main result* | Reference |
---|---|---|---|---|---|---|
BM-MSC | Rat | MI | Rat | 1.2 × 107, two sheets | VEGF BM-MSC sheet (++); BM-MSC sheet (+); Negative control | Augustin et al. [26] |
BM-MSC | Rat | MI | Rat | 4.0 × 106, one sheet | BM-MSC sheet (+) Negative control | Narita et al. [10] |
BM-MSC | Human | ICM | Porcine | 1.0 × 108, 10 sheets | BM-MSC sheet (+) Negative control | Kawamura et al. [27] |
BM-MSC | Rabbit | MI | Rabbit | - | Hypoxic conditioned BM-MSC sheet (++) BM-MSC sheet (+) Negative control | Tanaka et al. [28] |
BM-MSC | Rat | MI | Rat | 4.0 × 106, one sheet | Autologous BM-MSC sheet (+) Allogeneic BM-MSC sheet (+) Negative control | Tano et al. [29] |
AD-MSC | Rat | MI | Rat | ~9.0 × 106, one sheet | AD-MSC sheet (+) Dermal fibroblasts sheet Negative control | Miyahara et al. [30] |
AD-MSC | Human | MI | Rat | - | AD-MSC sheet (+) Cardiomyoblast-like sheet (++) Negative control | Okura et al. [31] |
AD-MSC | Porcine | HF | Porcine | Three-layered sheets | AD-MSC sheet (+) Negative control | Ishida et al. [32] |
AD-MSC | Mouse | MI | Mouse | One sheet | AD-MSC sheet (+) Intraperitoneal injection (+) Negative control | Kim et al. [9] |
UC-MSC | Human | MI | Mouse | ~1.0 × 106, one sheet | UC-MSC sheet (++) UC-MSC suspension (+) Negative control | Guo et al [33] |