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Table 1 Administration of MSC sheets in animal models

From: Application of mesenchymal stem cell sheet to treatment of ischemic heart disease

Cell type

Cell source

Disease model

Animal species

Number of cells

Groups and main result*

Reference

BM-MSC

Rat

MI

Rat

1.2 × 107, two sheets

VEGF BM-MSC sheet (++); BM-MSC sheet (+);

Negative control

Augustin et al. [26]

BM-MSC

Rat

MI

Rat

4.0 × 106, one sheet

BM-MSC sheet (+)

Negative control

Narita et al. [10]

BM-MSC

Human

ICM

Porcine

1.0 × 108, 10 sheets

BM-MSC sheet (+)

Negative control

Kawamura et al. [27]

BM-MSC

Rabbit

MI

Rabbit

-

Hypoxic conditioned BM-MSC sheet (++)

BM-MSC sheet (+)

Negative control

Tanaka et al. [28]

BM-MSC

Rat

MI

Rat

4.0 × 106, one sheet

Autologous BM-MSC sheet (+)

Allogeneic BM-MSC sheet (+)

Negative control

Tano et al. [29]

AD-MSC

Rat

MI

Rat

~9.0 × 106, one sheet

AD-MSC sheet (+)

Dermal fibroblasts sheet

Negative control

Miyahara et al. [30]

AD-MSC

Human

MI

Rat

-

AD-MSC sheet (+)

Cardiomyoblast-like sheet (++)

Negative control

Okura et al. [31]

AD-MSC

Porcine

HF

Porcine

Three-layered sheets

AD-MSC sheet (+)

Negative control

Ishida et al. [32]

AD-MSC

Mouse

MI

Mouse

One sheet

AD-MSC sheet (+)

Intraperitoneal injection (+)

Negative control

Kim et al. [9]

UC-MSC

Human

MI

Mouse

~1.0 × 106, one sheet

UC-MSC sheet (++)

UC-MSC suspension (+)

Negative control

Guo et al [33]

  1. *The symbols (+) and (++) indicate the result of the individual study only
  2. MI myocardial infarction, ICM ischemic cardiomyopathy, HF heart failure