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Table 1 Administration of MSC sheets in animal models

From: Application of mesenchymal stem cell sheet to treatment of ischemic heart disease

Cell type Cell source Disease model Animal species Number of cells Groups and main result* Reference
BM-MSC Rat MI Rat 1.2 × 107, two sheets VEGF BM-MSC sheet (++); BM-MSC sheet (+);
Negative control
Augustin et al. [26]
BM-MSC Rat MI Rat 4.0 × 106, one sheet BM-MSC sheet (+)
Negative control
Narita et al. [10]
BM-MSC Human ICM Porcine 1.0 × 108, 10 sheets BM-MSC sheet (+)
Negative control
Kawamura et al. [27]
BM-MSC Rabbit MI Rabbit - Hypoxic conditioned BM-MSC sheet (++)
BM-MSC sheet (+)
Negative control
Tanaka et al. [28]
BM-MSC Rat MI Rat 4.0 × 106, one sheet Autologous BM-MSC sheet (+)
Allogeneic BM-MSC sheet (+)
Negative control
Tano et al. [29]
AD-MSC Rat MI Rat ~9.0 × 106, one sheet AD-MSC sheet (+)
Dermal fibroblasts sheet
Negative control
Miyahara et al. [30]
AD-MSC Human MI Rat - AD-MSC sheet (+)
Cardiomyoblast-like sheet (++)
Negative control
Okura et al. [31]
AD-MSC Porcine HF Porcine Three-layered sheets AD-MSC sheet (+)
Negative control
Ishida et al. [32]
AD-MSC Mouse MI Mouse One sheet AD-MSC sheet (+)
Intraperitoneal injection (+)
Negative control
Kim et al. [9]
UC-MSC Human MI Mouse ~1.0 × 106, one sheet UC-MSC sheet (++)
UC-MSC suspension (+)
Negative control
Guo et al [33]
  1. *The symbols (+) and (++) indicate the result of the individual study only
  2. MI myocardial infarction, ICM ischemic cardiomyopathy, HF heart failure