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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: LINGO-1 regulates Wnt5a signaling during neural stem and progenitor cell differentiation by modulating miR-15b-3p levels

Fig. 5

miR-15b-3p is downregulated in LINGO-1 shRNA-treated sp-NSPCs, resulting in increased expression of Wnt5a. A Wnt5a protein levels increased after LINGO-1 shRNA treatment. However, B its mRNA levels did not change. C Volcano plot analysis of miRNA levels between LINGO-1 shRNA and control NSPC groups. D qPCR of miRNAs in the two sp-NSPC groups showing miR-15b-3p was downregulated after LINGO-1 RNA interference. E Levels of p-JNK, JNK, and F β-catenin in LINGO-1 shRNA-treated sp-NSPCs. *P < 0.05. Results are expressed as the mean ± SD. All of the analysis was calculated based on three biological replicates

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Stem Cell Research & Therapy

ISSN: 1757-6512