Fig. 7

Transplantation of LINGO-1 shRNA-treated sp-NSPCs after SCI improves neuronal differentiation, has a cavity-filling effect, and promotes tissue repair. Immunofluorescent staining of sagittal sections of thoracic spinal cords at 35 d.p.i. showing A, B more differentiated neurons, as revealed by DCX staining; C, D less differentiated astrocytes, as revealed by GFAP staining; E, F reduced lesion volume, as revealed by CSPG staining; and G, H less cavities, as revealed by GFAP staining. n = 10 animals per group, unpaired two-tailed Student’s t-test. ^*P < 0.05. Results are expressed as the mean ± SD