Fig. 8

LINGO-1 downregulation is required for functional recovery after SCI. Time course of locomotor recovery in the LINGO-1 shRNA and control groups evaluated by means of A the 9-point Basso Mouse Scale (BMS) and B the 11-point BMS subscore. Motor function measured with the rotarod test (C duration and D speed) at 35 d.p.i. n = 10 animals per group, repeated measures analysis of variance (rmANOVA) with Bonferroni post hoc correction for BMS and the BMS subscore, unpaired two-tailed Student’s t-test for the rotarod test. ^*P < 0.05. Results are expressed as the mean ± SD