Fig. 4

In vivo anti-arthritic potential of RA patient-derived SF-MSCs. a Evaluation of the clinical scores and measurements of hind paw thickness in CIA mice after intraperitoneal administration of SF-MSCs or PBS. b Images of micro-CT scanning and bone surface/bone volume (BS/BV) analysis. c and d Histological examination of therapeutic effects of SF-MSCs. In the HE staining, Ti represents tibia, Ta represents talus, and Ca represents calcaneus as the anatomical locations. 40× or 200× magnification. Graphs summarize the pathological scores in terms of inflammation, cartilage damage, and TRAP + cell (osteoclast) populations in joints from CIA mice. The asterisks indicate significant differences. The data represent the mean values ± SD. PBS, phosphate-buffered saline; H&E, hematoxylin and eosin; TRAP, tartrate resistant acid phosphatase. In the HE staining (panel c), Ti represents tibia, Ta represents talus, and Ca represents calcaneus as the anatomical locations