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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway

Fig. 7

Representative photomicrographs of CD31 immune stained sections showing the endothelial cells of the blood capillaries of different experimental groups (AK). A Group I (unwounded group): showing a moderate reaction (arrowhead) in the capillaries. B Group II (wounded and non-diabetic); IIa: showing a weak reaction (arrowhead) in few capillaries. C Group IIb: strong reaction (arrowhead) in many capillaries.D, E Groups III a & b (diabetic groups): negative reaction (arrowhead) in the capillaries. F Group IV (DM+ PRP group); IVa: showing a moderate reaction (arrowhead) in some capillaries. G Group IVb: showing a strong reaction in the capillaries. H Group V (DM+ADSC group); Va: showing a mild reaction in the capillaries. I Group Vb: showing a moderate reaction in the capillaries. J, K Groups VI a & b (DM+ADSCs +PRP group): showing a strong reaction in both days with an increase in the number of capillaries seen on the 14th day. l Vascular area density/vascular index in the different experimental groups. n= 7 per group. Data are expressed as median (maximum and minimum), **significant compared to the control group at p<0.01, $$significant compared to the Sham group at p<0.01, ##significant compared to the diabetic group at p<0.01, ~significant compared to group V at p<0.05, and ~~significant compared to group IV at p<0.01

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