Table 4 Differently expressed genes selected (model group/young group)
Symbol | Gene name | log2FC | Significance |
|---|---|---|---|
Xab2 | XPA-binding protein 2 | − 1.02 | DNA repair |
Sirt3 | Sirtuin 3 | − 1.04 | Chromatin silencing |
Sirt | Sirtuin | − 1.57 | Chromatin silencing |
Rad52 | RAD52 homolog | − 1.62 | DNA repair |
Xrcc3 | X-ray repair comp. defective repair in C. hamster cells 3 | − 2.32 | DNA repair |
Eng | Endoglin | − 2.81 | TGF-b regulates HSPCs pool size |
Blm | Bloom syndrome homolog | − 1.48 | DNA repair |
Sirt | Sirtuin 2 | − 1.57 | Chromatin silencing |
App | Amyloid beta precursor protein | 4 | Alzheimer disease, stress response |
Selp | Platelet-selectin | 2.47 | Inflammation, adhesion |
Ctsb | Cathepsin B | 3.56 | APP processing, Alzheimer |
Ctsc | Cathepsin C | 4.85 | Proteolysis, inflammation |
Icam1 | Intercellular adhesion 1 | 4.2 | Cell-cell adhesion, inflammation |
Ctss | Cathepsin S | 7.4 | Proteolysis, inflammation |
Cct6a | Chaperonin subunit 6a (zeta) | 1.34 | Protein folding |
Dnajb6 | DnaJ (Hsp40) homolog B6 | 2.8 | Protein folding |
Tlr4 | Toll-like receptor 4 | 2.08 | Inflammation |