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Table 3 BV/TV: stratified analysis of MSC-treated vs. control

From: Systemic therapy of MSCs in bone regeneration: a systematic review and meta-analysis

  Subgroup N Effect estimate I2 p* p**
Species of animals Mice 11 1.97 (0.98, 2.95) 78% p<0.00001 N
Rat Not calculated   
Types of MSCs BMSCs 10 1.55 (0.71, 2.39) 71% p=0.0002 N
other MSCs Not calculated  
Frequency of injection Single injection 10 1.96 (0.88, 3.03) 77% p<0.00001 N
Multiple injection Not calculated
Time of injection At the same time of modeling Not calculated N
After modeling 12 1.83 (0.92, 2.73) 76% p<0.00001
Bone diseases Bone defect 8 1.77 (0.64, 2.89) 82% p<0.00001 p=0.03
Systematic bone diseases 5 4.27 (2.26, 6.27) 50% p=0.09  
Sex of animals Male 6 1 (0.12, 1.88) 75% p=0.001 N
Female Not calculated
  1. p* value for heterogeneity within each subgroup. p** value for heterogeneity between subgroups with meta-regression analysis. MSCs, mesenchymal stem cells; BMSCs, bone marrow-derived mesenchymal stem cells