Table 3 BV/TV: stratified analysis of MSC-treated vs. control
From: Systemic therapy of MSCs in bone regeneration: a systematic review and meta-analysis
| Â | Subgroup | N | Effect estimate | I2 | p* | p** |
|---|---|---|---|---|---|---|
Species of animals | Mice | 11 | 1.97 (0.98, 2.95) | 78% | p<0.00001 | N |
Rat | Not calculated | Â | Â | |||
Types of MSCs | BMSCs | 10 | 1.55 (0.71, 2.39) | 71% | p=0.0002 | N |
other MSCs | Not calculated | Â | ||||
Frequency of injection | Single injection | 10 | 1.96 (0.88, 3.03) | 77% | p<0.00001 | N |
Multiple injection | Not calculated | |||||
Time of injection | At the same time of modeling | Not calculated | N | |||
After modeling | 12 | 1.83 (0.92, 2.73) | 76% | p<0.00001 | ||
Bone diseases | Bone defect | 8 | 1.77 (0.64, 2.89) | 82% | p<0.00001 | p=0.03 |
Systematic bone diseases | 5 | 4.27 (2.26, 6.27) | 50% | p=0.09 | Â | |
Sex of animals | Male | 6 | 1 (0.12, 1.88) | 75% | p=0.001 | N |
Female | Not calculated | |||||