Fig. 5

Glioma cells cultivated in gaMSC-conditioned media show activated EMT process and increased TMZ resistance ability in tumour-bearing mice. Representative mice from intracranial xenograft experiments in which U87 cells at different conditions were injected into the right frontal lobes of nude mice, tumour sizes of U87MG treated with TMZ were showed in A (n = 3). Then, tumour volume (B), EMT markers (C), survival time (D), Ki67-staining (E) and apoptosis assay (F) were investigated in tumour-bearing mice inoculated with mo.U87/co.U87 and treated with TMZ (× 400, scale bar = 250 μm, n = 3, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)