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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Mesenchymal stem cells alleviate idiopathic pneumonia syndrome by modulating T cell function through CCR2-CCL2 axis

Fig. 1

Effect of MSCs on T cell activation. T cells were pre-activated by adding CD3/CD28 monoclonal antibodies for 4 h and then co-cultured with MSCs for 72 h. T cells were collected at different time points to detect the effect of MSCs on T cell activation (a) in the contacting culture system or b by isolating MSCs and T cells in the Transwell system. c The inhibitory effect of MSCs on T cell activation in mixed lymphocyte reaction (MLR) when co-cultured with MSCs in the contacting culture system. T cell activation status was analyzed for detection of CD69-positive T cells using flow cytometry. n = 5, *P <0.05; **P <0.01; ***P <0.001

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