Skip to main content
Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Mesenchymal stem cells alleviate idiopathic pneumonia syndrome by modulating T cell function through CCR2-CCL2 axis

Fig. 6

Application of CCR2/CCL2 antagonists impair the prophylactic effect of MSCs on IPS. In the IPS mouse model, CCL2 or CCR2 antagonist was used to block the interaction of CCL2 with CCR2 in vivo to observe the effect of MSCs on a survival rate, b weight changes, c clinical scores of GVHD, and d lung injury. e The representative pathological results of lung injury related to different conditions. f The representative pathological result of CD3+ T cell infiltration observed after immunohistochemical staining. g CD69+ T cells, h CCR2-expressing T cells, and i CCR2+CD4+ T cells in T cells isolated from lung tissue. n=9, *P < 0.05; **P < 0.01; ***P < 0.001. n.s., no statistical difference

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512