Table 4 Cytokines and chemokines changes
Low dose | Middle dose | High dose | ||||||
|---|---|---|---|---|---|---|---|---|
var | avg_change | p_value | var | avg_change | p_value | var | avg_change | p_value |
EGF | 12.94 | 0.082 | EGF | − 1.33 | 0.6061 | EGF | 16 | 0.1777 |
FGF2 | − 0.83 | 0.7778 | FGF2 | 5.18 | 0.0035* | FGF2 | 3.14 | 0.0581 |
Eotaxin | 4.92 | 0.1053 | Eotaxin | 2.76 | 0.0043* | Eotaxin | 4.72 | 0.3712 |
TGF_alph | 0.14 | 0.4226 | TGF_alph | 0.21 | 0.4226 | TGF_alph | 0 | 1 |
G_CSF | 0.64 | 0.4226 | G_CSF | 10.48 | 0.288 | G_CSF | 0.6 | 0.7915 |
Flt_3L | 0 | 1 | Flt_3L | 0 | 1 | Flt_3L | 1.38 | 0.4226 |
GM_CSF | − 0.5 | 0.4226 | GM_CSF | 1.01 | 0.1904 | GM_CSF | 0.01 | 0.99 |
Fractalk | − 19.1 | 0.0104* | Fractalk | − 0.44 | 0.4226 | Fractalk | 8.77 | 0.4226 |
IFN_alph | 0 | 1 | IFN_alph | 0.22 | 0.4226 | IFN_alph | 0.26 | 0.4226 |
IFN_gamm | − 0.85 | 0.3704 | IFN_gamm | − 1.32 | 0.4114 | IFN_gamm | 1.49 | 0.4382 |
GRO | 77.88 | 0.3749 | GRO | 47.98 | 0.2373 | GRO | − 2.21 | 0.9386 |
IL_10 | 0 | 1 | IL_10 | − 1.45 | 0 4802 | IL_10 | 0 | 1 |
MCP_3 | 0 | 1 | MCP_3 | 3.66 | 0.2609 | MCP_3 | 0.86 | 0.4226 |
IL_12p40 | 0 | 1 | IL_12p40 | 0 | 1 | IL_12p40 | 0 | 1 |
MDC | 22.33 | 0.3761 | MDC | 55.89 | 0.0446* | MDC | 5.01 | 0.8816 |
IL_12p7 0 | 0 | 1 | IL_12p7 0 | 0.53 | 0.4226 | IL_12p7 0 | 0.26 | 0.4226 |
IL_13 | 0 | 1 | IL_13 | − 0.37 | 0.8552 | IL_13 | 1.06 | 0.4624 |
IL_15 | 0 | 1 | IL_15 | 0.29 | 0.4226 | IL_15 | 0.06 | 0.4226 |
sCD40L | 1714.04 | 0.2155 | sCD40L | 488.89 | 0.2467 | sCD40L | 594.57 | 0.0859 |
IL_17A | − 0.83 | 0.2321 | IL_17A | − 0.56 | 0.1837 | IL_17A | 0.17 | 0.8197 |
IL_1RA | − 1.93 | 0.672 | IL_1RA | − 0.57 | 0.8492 | IL_1RA | 0.8 | 0.4226 |
IL_1alph | 0 | 1 | IL_1alph | 0.68 | 0.9572 | IL_1alph | 7.64 | 0.4226 |
IL_9 | 0 | 1 | IL_9 | − 0.09 | 0.4226 | IL_9 | 0.34 | 0.4226 |
IL_lbeta | 0 | 1 | IL_lbeta | 0 | 1 | IL_lbeta | 0 | 1 |
IL_2 | 0 | 1 | IL_2 | − 0.22 | 0.4226 | IL_2 | 0 | 1 |
IL_3 | 0 | 1 | IL_3 | 0 | 1 | IL_3 | 0 | 1 |
IL_4 | 6.48 | 0.315 | IL_4 | 23.67 | 0.4287 | IL_4 | 11.83 | 0.4226 |
IL_5 | − 0.35 | 0.4226 | IL_5 | − 0.34 | 0.4226 | IL_5 | 0.26 | 0.4226 |
IL_6 | 0 | 1 | IL_6 | 2.2 | 0.3444 | IL_6 | 1.16 | 0.4226 |
IL_7 | − 0.48 | 0.3651 | IL_7 | 1.54 | 0.1542 | IL_7 | − 0.86 | 0.5098 |
IL_8 | 0.7 | 0.2546 | IL_8 | 1.8 | 0.0705 | IL_8 | 0.77 | 0.556 |
IP_10 | 13.45 | 0.4772 | IP_10 | − 0.6 | 0.9709 | IP_10 | − 16.72 | 0.2174 |
MCP_1 | 21.64 | 0.0008* | MCP_1 | 15.45 | 0.0039 | MCP_1 | 12.5 | 0.5057 |
MIP_lalp | 0.85 | 0.4452 | MIP_lalp | − 1.36 | 0.1323 | MIP_lalp | 3.11 | 0.3513 |
MIP_lbet | 3.73 | 0.3903 | MIP_lbet | 9.02 | 0.0989 | MIP_lbet | 5.28 | 0.2209 |
TNF_alph | 1.22 | 0.2699 | TNF_alph | − 0.74 | 0.0006 | TNF_alph | 4.87 | 0 4082 |
TNF_beta | 0 | 1 | TNF_beta | 4.28 | 0.3584 | TNF_beta | 1.52 | 0.4226 |
VEGF | − 3.67 | 0.651 | VEGF | 20.11 | 0.1275 | VEGF | 7.56 | 0.2767 |