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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1α/CXCR4

Fig. 2

Meox1 promoted Sca-1-positive stem cell migration into neointima. A Fluorescence staining for Sca-1 in injured arteries treated with or without Ad-shMeox1 for 14 days. Round arrow indicates the neointima area, open arrow indicates the media, and forked tail arrow indicates the adventitia. B–D The number of Sca-1+ progenitor cells were determined within the media or intima of A by Image-Pro Plus software. Six rats each group, random three high power visual field each section, n = 6, &P < 0.05 vs. the injured arteries treated with Ad-Null. E The I/M ratio from A, *P < 0.05 vs. Ad-Null. F Response of human umbilical cord Sca-1 progenitor cell migration to conditioned medium (CM) of VSMC treated with or without Ad-Meox1. G Quantitative analysis of cell migration was analyzed using the Transwell system. n = 15, *P < 0.05 vs. CM-Ctrl; #P < 0.05 vs. CM-Ad-Meox1. I, neointima; M, media; A, adventitia

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Stem Cell Research & Therapy

ISSN: 1757-6512